Adding carbamazepine to quetiapine.
- Quetiapine is principally metabolized by CYP3A4 to active and inactive metabolites.
- Carbamazepine is principally metabolized by CYP3A4, and is a potent inducer of CYP1A2, CYP2C9, CYP3A4 and UDP-glucuronosyltransferases.
- This combination of drugs may have possible synergistic effects. However, the pharmacokinetic drug interactions will influence the plasma levels. Dose adaptation will be recommended for this combination.
- Start carbamazepine according to the general dosing advice.
- The pharmacologic response to quetiapine should be monitored more closely. Dose adoptation of quetiapine could be necessary.
- Carbamazepine can reduce quetiapine serum concentration, possible below therapeutic range. 
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