Switch medication from mirtazapine to amitriptyline.
- Before day 1: gradually reduce dosage of mirtazapine to a maximum of 30 mg/ day.
- Day 1: reduce a dosage of 30 mg/day to 15 mg/day.
- Day 8: stop administration of mirtazapine.
No wash-out period is needed.
- Day 1: simultaneously start administration of amitriptyline in a dosage of 50 mg/day.
- Day 8: If necessary, increase dosage of amitriptyline.
- Start low, go slow.
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