Difference between revisions of "Amitriptyline-citalopram"

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* Citalopram/escitalopram is a weak inhibitor of CYP2D6, which metabolizes amitriptyline. 
 
 
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Revision as of 13:45, 1 September 2009

Amitriptyline
Type Antidepressant
Group TCA
links
ATC-code N06AA09
Medscape Amitriptyline
PubChem 2160
PubMed Amitriptyline
Kompas (Dutch) Amitriptyline
Wikipedia Amitriptyline
Citalopram
Type Antidepressant
Group SSRI
links
ATC-code N06AB04
Medscape Citalopram
PubChem 2771
PubMed Citalopram
Kompas (Dutch) citalopram
Wikipedia citalopram

Switch medication from amitriptyline to citalopram.

Nietinrijdenbord.png Stop amitriptyline
  • Before day 0: gradually reduce dosage of amitriptyline to a maximum of 50 mg/day.
  • Day 1: reduce dosage of amitriptyline to 25 mg/day.
  • Day 8: stop administration of amitriptyline.
Eenrichtingbord.png Start citalopram
  • Day 8: start administration of citalopram/escitalopram in a normal dosage of 20 mg/day, resp. 10 mg/day.
Infobord.png More information
  • Occurrence of the serotonin syndrome is not likely, but theoretically possible, so caution is necessary.
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