Difference between revisions of "Amitriptyline-doxepine"

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Revision as of 16:46, 28 October 2015

Amitriptyline
Type Antidepressant
Group TCA
links
ATC-code N06AA09
Medscape Amitriptyline
PubChem 2160
PubMed Amitriptyline
Kompas (Dutch) Amitriptyline
Wikipedia Amitriptyline
Doxepin
Type antidepressant
Group TCA
links
ATC-code N06AA12
Medscape Doxepin
PubChem 3158
PubMed Doxepin
Drugs.com doxepin
Kompas (Dutch) Doxepin
Wikipedia Doxepin

Switch medication from amitriptyline to doxepin.[2] [3]

Nietinrijdenbord.png Stop amitriptyline
  • Gradually reduce dosage of amitriptyline to a maximum of 50-100 mg/day.
  • When a dosage of 50 mg/day is reached, stop administration.
Eenrichtingbord.png Start doxepin
  • No wash-out period is needed.
  • Start administration of doxepin the next day in a normal dosage of 50 mg/day.
Infobord.png More information
  • Both drugs are a TCA with anticholinergic properties, so a switch to a relatively high starting dose can be made.
  • This switch is currently being reviewed.
  1. 1.0 1.1 1.2 1.3 1.4 KNMP; Informatorium Medicamentorum 2023; Monografie "doxepine" (Dutch)
  2. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  3. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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