Difference between revisions of "Amitriptyline-escitalopram"

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* '''Before day 1:''' gradually reduce dosage of amitriptyline to a maximum of 50 mg/day.
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{{stopAmitriptyline1}}
* '''Day 1:''' reduce dosage of amitriptyline to 25 mg/day.
 
* '''Day 8:''' stop administration of amitriptyline.
 
 
| start = {{StartEscitalopram}}
 
| start = {{StartEscitalopram}}
 
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Revision as of 12:49, 2 November 2015

Amitriptyline
Type Antidepressant
Group TCA
links
ATC-code N06AA09
Medscape Amitriptyline
PubChem 2160
PubMed Amitriptyline
Kompas (Dutch) Amitriptyline
Wikipedia Amitriptyline
Escitalopram
Type Antidepressant
Group SSRI
links
Medscape Escitalopram
PubChem 10832572
PubMed Escitalopram
Kompas (Dutch) Escitalopram
Wikipedia Escitalopram

Switch medication from amitriptyline to escitalopram.[1] [2]

Nietinrijdenbord.png Stop amitriptyline
  • Before day 1: gradually reduce dosage of amitriptyline to a maximum of 100 mg/day, when this dosage is > 100 mg/day.
  • Day 1: reduce dosage of amitriptyline to 50 mg/day.
  • Day 8: reduce dosage of amitriptyline to 25 mg/day.
  • Day 15: stop administration of amitriptyline.
Eenrichtingbord.png Start escitalopram
  • Day 8: start administration of escitalopram in a normal dosage of 10 mg/day.
  • Day 15: if necessary, increase dosage of escitalopram.
Infobord.png More information
  • Occurrence of the serotonin syndrome is not likely, but theoretically possible, so caution is necessary.
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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