Difference between revisions of "Amitriptyline-fluvoxamine"

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* '''Day 15:''' increase administration of fluvoxamine.
 
* '''Day 15:''' increase administration of fluvoxamine.
 
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* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.
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* {{theorSS}}
 
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Revision as of 16:12, 6 August 2009

Amitriptyline
Type Antidepressant
Group TCA
links
ATC-code N06AA09
Medscape Amitriptyline
PubChem 2160
PubMed Amitriptyline
Kompas (Dutch) Amitriptyline
Wikipedia Amitriptyline
Fluvoxamine
Type Antidepressant
Group SSRI
links
Medscape Fluvoxamine
PubChem 5324346
PubMed Fluvoxamine
Kompas (Dutch) Fluvoxamine
Wikipedia Fluvoxamine

Switch medication from amitriptyline to fluvoxamine.[1] [2]

Nietinrijdenbord.png Stop amitriptyline
  • Before day 0: gradually reduce dosage of amitriptyline to a maximum of 50 mg/day.
  • Day 1: reduce dosage of amitriptyline to 25 mg/day.
  • Day 8: stop dosage of amitriptyline.
Eenrichtingbord.png Start fluvoxamine
  • Day 8: simultaneously start administration of fluvoxamine in a normal dosage of 50 mg/day.
  • Day 15: increase administration of fluvoxamine.
Infobord.png More information
  • Occurrence of the serotonin syndrome is not likely, but theoretically possible, so caution is necessary.
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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