Difference between revisions of "Amitriptyline-imipramine"

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| from = amitriptyline  
 
| from = amitriptyline  
 
| to = imipramine  
 
| to = imipramine  
| stop = * Gradually reduce dosage of amitriptyline to a maximum of 50-100 mg/day.
+
| stop =  
* When a dosage of 50-100 mg/day is reached, stop administration.
+
{{stopAmitriptyline}}
 
| start =  
 
| start =  
 
* No wash-out period is needed.  
 
* No wash-out period is needed.  
* Start administration of imipramine the next day in a normal dosage of 50-100 mg/day.
+
* ''' Day 9: start administration of imipramine in a normal dosage of 50-100 mg/day.
 
| info =
 
| info =
 
* {{TCAantichol}}
 
* {{TCAantichol}}
{{review}}
 
 
}}
 
}}

Revision as of 13:05, 2 November 2015

Amitriptyline
Type Antidepressant
Group TCA
links
ATC-code N06AA09
Medscape Amitriptyline
PubChem 2160
PubMed Amitriptyline
Kompas (Dutch) Amitriptyline
Wikipedia Amitriptyline
Imipramine
Type Antidepressant
Group TCA
links
Medscape Imipramine
PubChem 3696
PubMed Imipramine
Kompas (Dutch) Imipramine
Wikipedia Imipramine

Switch medication from amitriptyline to imipramine.[1] [2]

Nietinrijdenbord.png Stop amitriptyline
  • Before day 1: gradually reduce dosage of amitriptyline to a maximum of 50-100 mg/ day, when this dosage is > 100 mg/day.
  • Day 1-3: reduce dosage of amitriptyline to 50 mg/day.
  • Day 4-7: reduce dosage of amitriptyline to 25 mg/day.
  • Day 8: stop administration of amitriptyline.
Eenrichtingbord.png Start imipramine
  • No wash-out period is needed.
  • Day 9: start administration of imipramine in a normal dosage of 50-100 mg/day.
Infobord.png More information
  • Both drugs are a TCA with anticholinergic properties, so a switch to a relatively high starting dose can be made.
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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