Amitriptyline-paroxetine

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Amitriptyline
Type Antidepressant
Group TCA
links
ATC-code N06AA09
Medscape Amitriptyline
PubChem 2160
PubMed Amitriptyline
Kompas (Dutch) Amitriptyline
Wikipedia Amitriptyline
paroxetine
Type Antidepressant
Group SSRI
links
Medscape paroxetine
PubChem 43815
PubMed paroxetine
Kompas (Dutch) paroxetine
Wikipedia paroxetine

Switch medication from amitriptyline to paroxetine.

Nietinrijdenbord.png Stop amitriptyline
  • Before day 1: gradually reduce dosage of amitriptyline to a maximum of 50-100 mg/ day, when this dosage is > 100 mg/day.
  • Day 1-3: reduce dosage of amitriptyline to 50 mg/day.
  • Day 4-7: reduce dosage of amitriptyline to 25 mg/day.
  • Day 8: stop administration of amitriptyline.
Eenrichtingbord.png Start paroxetine
  • Day 9: start administration of paroxetine in a normal dosage of 20 mg/day.
  • Day 16: increase dosage of paroxetine if necessary.
Infobord.png More information
  • Occurrence of the serotonin syndrome is not likely, but theoretically possible, so caution is necessary.
  • Paroxetine is a strong inhibitor of CYP2D6, which metabolizes amitriptyline.
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