Difference between revisions of "Amitriptyline-tranylcypromine"

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Revision as of 15:10, 28 October 2015

Amitriptyline
Type Antidepressant
Group TCA
links
ATC-code N06AA09
Medscape Amitriptyline
PubChem 2160
PubMed Amitriptyline
Kompas (Dutch) Amitriptyline
Wikipedia Amitriptyline
Tranylcypromine
Type Antidepressant
Group MAO-I
links
Medscape Tranylcypromine
PubChem 5530
PubMed Tranylcypromine
Kompas (Dutch) Tranylcypromine
Wikipedia Tranylcypromine

Switch medication from amitriptyline to tranylcypromine.[1] [2]

Nietinrijdenbord.png Stop amitriptyline
  • Before day 1: gradually reduce dosage of amitriptyline to a maximum of 50-100 mg/ day, when this dosage is > 100 mg/day.
  • Day 1-3: reduce dosage of amitriptyline to 50 mg/day.
  • Day 4-7: reduce dosage of amitriptyline to 25 mg/day.
  • Day 8: stop administration of amitriptyline.
Eenrichtingbord.png Start tranylcypromine
  • Day 8-21: a wash-out period of two weeks is necessary.
  • Day 22: start administration of tranylcypromine in a low dosage of 20 mg/day for one week.
  • Day 29: after this week the dosage of tranylcypromine can be increased if necessary.
Letopbord.png Cave
Infobord.png More information
  • This switch is currently being reviewed.
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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