Difference between revisions of "Amitriptyline-trazodone"

From Psychiatrienet
Jump to: navigation, search
 
(One intermediate revision by the same user not shown)
Line 3: Line 3:
 
| to = trazodone  
 
| to = trazodone  
 
| stop =  
 
| stop =  
* '''Before day 1:''' gradually reduce dosage of amitriptyline to a maximum of 50 mg/ day, when this dosage is > 50 mg/day.
+
{{stopAmitriptyline}}
* '''Day 1:''' reduce dosage of amitriptyline to 25 mg/day.
 
* '''Day 8:''' stop administration of amitriptyline.
 
 
| start =  
 
| start =  
 
No wash-out period is needed.  
 
No wash-out period is needed.  
* '''Day 1:''' simultaneously start administration of trazodone in a dosage of 150 mg/day.
+
* '''Day 4:''' simultaneously start administration of trazodone in a dosage of 150 mg/day.
* '''Day 8:''' continue only administration of trazodone. If necessary, increase the dosage of trazodone to a maximum of 400 mg/day.
+
* '''Day 12:''' if necessary, increase the dosage of trazodone to a maximum of 400 mg/day.
 
| info =  
 
| info =  
* Occurrence of the serotonin syndrome is theoretically possilble, so caution is necessary.
+
* {{theorSS}}
{{review}}
 
 
}}
 
}}

Latest revision as of 14:03, 2 November 2015

Amitriptyline
Type Antidepressant
Group TCA
links
ATC-code N06AA09
Medscape Amitriptyline
PubChem 2160
PubMed Amitriptyline
Kompas (Dutch) Amitriptyline
Wikipedia Amitriptyline
Trazodone
Type Antidepressant
Group other
links
Medscape Trazodone
PubChem 5533
PubMed Trazodone
Kompas (Dutch) Trazodone
Wikipedia Trazodone

Switch medication from amitriptyline to trazodone.

Nietinrijdenbord.png Stop amitriptyline
  • Before day 1: gradually reduce dosage of amitriptyline to a maximum of 50-100 mg/ day, when this dosage is > 100 mg/day.
  • Day 1-3: reduce dosage of amitriptyline to 50 mg/day.
  • Day 4-7: reduce dosage of amitriptyline to 25 mg/day.
  • Day 8: stop administration of amitriptyline.
Eenrichtingbord.png Start trazodone

No wash-out period is needed.

  • Day 4: simultaneously start administration of trazodone in a dosage of 150 mg/day.
  • Day 12: if necessary, increase the dosage of trazodone to a maximum of 400 mg/day.
Infobord.png More information
  • Occurrence of the serotonin syndrome is not likely, but theoretically possible, so caution is necessary.
The editors of psychiatrienet.nl take the greatest care to provide up-to-date and accurate information on this site. Nevertheless, mistakes and omissions cannot be entirely excluded. No rights devolve from the information provided. The editors and other providers of information to this site accept no responsibility for the content of this site or for the information provided therein; neither do they accept responsibility for possible damages which may derive from the use of the information on this site or from the linked sites. The editorial board accepts no responsibility for the content of the (linked) sites, for access to them, or for the products and services on these sites, nor for the occurrence of errors, viruses, and/or disruptions in service.