Difference between revisions of "Amitriptyline-venlafaxine"

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| to = venlafaxine  
 
| to = venlafaxine  
 
| stop =  
 
| stop =  
* '''Day 0:''' gradually reduce dosage of amitriptyline to a maximum of 50-100 mg/ day, when this dosage is > 100 mg/day.
+
{{stopAmitriptyline}}.  
* '''Day 1-7:''' reduce dosage of amitriptyline to 25-50 mg/day.
 
* '''Day 8:''' stop administration of amitriptyline.  
 
 
| start =  
 
| start =  
* '''Day 8-14:''' a wash-out period of one week is necessary.
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* '''Day 9-15:''' a wash-out period of one week is necessary.
* '''Day 15:''' {{startVenla}}
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* '''Day 16:''' {{startVenla}}
|info=
 
{{review}}
 
 
}}
 
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Revision as of 13:04, 2 November 2015

Amitriptyline
Type Antidepressant
Group TCA
links
ATC-code N06AA09
Medscape Amitriptyline
PubChem 2160
PubMed Amitriptyline
Kompas (Dutch) Amitriptyline
Wikipedia Amitriptyline
Venlafaxine
Type Antidepressant
Group SNRI
links
Medscape Venlafaxine
PubChem 5656
PubMed Venlafaxine
Kompas (Dutch) Venlafaxine
Wikipedia Venlafaxine

Switch medication from amitriptyline to venlafaxine.[1] [2]

Nietinrijdenbord.png Stop amitriptyline
  • Before day 1: gradually reduce dosage of amitriptyline to a maximum of 50-100 mg/ day, when this dosage is > 100 mg/day.
  • Day 1-3: reduce dosage of amitriptyline to 50 mg/day.
  • Day 4-7: reduce dosage of amitriptyline to 25 mg/day.
  • Day 8: stop administration of amitriptyline..
Eenrichtingbord.png Start venlafaxine
  • Day 9-15: a wash-out period of one week is necessary.
  • Day 16: Start administration of venlafaxine in a normal dosage of 37,5 mg or 75 mg (slow release) /day.


  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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