Bupropion-imipramine
From Psychiatrienet
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Switch medication from bupropion to imipramine.[1] [2]
Stop bupropion - Before day 1: Gradually reduce dosage of bupropion to a maximum of 150 mg/ day.
- Day 1: Stop administration of bupropion
Start imipramine- Day 1-3: start administration of imipramine the next day in a low dosage of 25 mg/day.
- Day 4: increase dosage of imipramine to 50 mg/day and continue slowly increasing the dosage depending on the condition of the patient.
More information- Bupropion slows the metabolism of imipramine via CYP2D6.
- Caution is necessary at the start of administration of imipramine.
- The concomitant use of bupropion and tricyclic antidepressants (TCAs) may potentiate the risk of seizures. These agents are all epileptogenic and may have additive effects on the seizure threshold.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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