Difference between revisions of "Clomipramine-escitalopram"

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* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.
 
* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.
* Escitalopram is a very weak inhibitors of CYP2D6, which metabolizes clomipramine.
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* Escitalopram is a very weak inhibitor of CYP2D6, which metabolizes clomipramine.
 
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Revision as of 12:01, 9 March 2010

Clomipramine
Type Antidepressant
Group TCA
links
ATC-code N06AA04
Medscape Clomipramine
PubChem 2801
PubMed Clomipramine
Kompas (Dutch) Clomipramine
Wikipedia Clomipramine
Escitalopram
Type Antidepressant
Group SSRI
links
Medscape Escitalopram
PubChem 10832572
PubMed Escitalopram
Kompas (Dutch) Escitalopram
Wikipedia Escitalopram

Switch medication from clomipramine to escitalopram.

Nietinrijdenbord.png Stop clomipramine
  • Before day 1: gradually reduce dosage of clomipramine to a maximum of 50 mg/day.
  • Day 1: reduce dosage of clomipramine to 25 mg/day.
  • Day 3: reduce dosage of clomipramine to 10 mg/day.
  • Day 8: stop administration of clomipramine.
Eenrichtingbord.png Start escitalopram
  • Day 1: simultaneously start administration of escitalopram in a normal dosage of 10 mg/day.
Infobord.png More information
  • Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.
  • Escitalopram is a very weak inhibitor of CYP2D6, which metabolizes clomipramine.
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