Difference between revisions of "Clomipramine-fluvoxamine"

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| to = fluvoxamine
 
| to = fluvoxamine
 
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| stop =  
* '''Before day 1:''' gradually reduce dosage of clomipramine to a maximum of 50 mg/day.
+
{{stopClomipramine}}
* '''Day 1:''' reduce dosage of clomipramine to 25 mg/day.
 
* '''Day 8:''' stop dosage of clomipramine.
 
 
| start =  
 
| start =  
* '''Day 8:''' start administration of fluvoxamine in a normal dosage of 50 mg/day.
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* '''Day 9:''' start administration of fluvoxamine in a normal dosage of 50 mg/day.
* '''Day 15:''' increase dosage of fluvoxamine.
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* '''Day 16:''' increase dosage of fluvoxamine.
 
| info =  
 
| info =  
* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.
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* {{theorSS}}
 
* Fluvoxamine is an inhibitor of CYP1A2, CYP2C19 and CYP3A4 (moderate), which metabolize clomipramine.
 
* Fluvoxamine is an inhibitor of CYP1A2, CYP2C19 and CYP3A4 (moderate), which metabolize clomipramine.
{{review}}}}
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Latest revision as of 13:00, 4 November 2015

Clomipramine
Type Antidepressant
Group TCA
links
ATC-code N06AA04
Medscape Clomipramine
PubChem 2801
PubMed Clomipramine
Kompas (Dutch) Clomipramine
Wikipedia Clomipramine
Fluvoxamine
Type Antidepressant
Group SSRI
links
Medscape Fluvoxamine
PubChem 5324346
PubMed Fluvoxamine
Kompas (Dutch) Fluvoxamine
Wikipedia Fluvoxamine

Switch medication from clomipramine to fluvoxamine.

Nietinrijdenbord.png Stop clomipramine
  • Before day 1: gradually reduce dosage of clomipramine to a maximum of 75 mg/ day, when this dosage is > 75 mg/day.
  • Day 1-3: reduce dosage of clomipramine to 50 mg/day.
  • Day 4-7: reduce dosage of clomipramine to 25 mg/day.
  • Day 8: stop administration of clomipramine.
Eenrichtingbord.png Start fluvoxamine
  • Day 9: start administration of fluvoxamine in a normal dosage of 50 mg/day.
  • Day 16: increase dosage of fluvoxamine.
Infobord.png More information
  • Occurrence of the serotonin syndrome is not likely, but theoretically possible, so caution is necessary.
  • Fluvoxamine is an inhibitor of CYP1A2, CYP2C19 and CYP3A4 (moderate), which metabolize clomipramine.
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