Adding quetiapine to carbamazepine.
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- Carbamazepine is principally metabolized by CYP3A4, and is a potent inducer of CYP1A2, CYP2C9, CYP3A4 and UDP-glucuronosyltransferases.
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- Quetiapine is principally metabolized by CYP3A4 to active and inactive metabolites.
- Carbamazepine can reduce quetiapine serum concentration, possible below therapeutic range. 
- Add quetiapine according to the general dosing advice and increase dose based on clinical effect or serum concentration.   
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