Combining-Gabapentin-Quetiapine

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Gabapentin
Type moodstabilizer
Group anticonvulsant
links
ATC-code N03AX12
PubChem 3446
PubMed Gabapentin
Drugs.com gabapentin
Kompas (Dutch) Gabapentin
Wikipedia Gabapentin
Quetiapine
Type antipsychotic
Group atypical AP
Other use moodstabilizer
links
ATC-code N05AH04
Medscape Quetiapine
PubChem 5002
PubMed Quetiapine
Drugs.com quetiapine-fumarate
Kompas (Dutch) Quetiapine
Wikipedia Quetiapine

Adding quetiapine to gabapentin.

Infobord.png General information
  • Gabapentin is eliminated unchanged by the kidney for 100%.
  • Quetiapine is principally metabolized by CYP3A4 to active and inactive metabolites.
  • This combination of drugs may have possible synergistic effects. There are no reports for pharmacokinetic drug interactions. However, the combination will have additional side effects. [6]
Eenrichtingbord.png Start quetiapine
  • Start quetiapine according to the general dosing advice.
Letopbord.png Cave
  • Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these effects. [5]


  1. Farmacotherapeutisch Kompas - gabapentine (dutch)
  2. 2.0 2.1 2.2 KNMP; Informatorium Medicamentorum 2023; Monografie "quetiapine" (Dutch)
  3. NVZA; Toxicology.org; Monografie 73 (dutch)
  4. Woods SW Chlorpromazine equivalent doses for the newer atypical antipsychotics J Clin Psychiatry 2003;64:663-667
  5. 5.0 5.1 Drugs.com quetiapine-fumarate Cite error: Invalid <ref> tag; name "drugscom" defined multiple times with different content
  6. Freeman et al. Mood stabilizer Combinations: A Review of Safety and Efficacy. Am J Psychiatry 1998;155:12-21
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