Combining-Lamotrigine-Carbamazepine

From Psychiatrienet
Revision as of 16:20, 22 April 2010 by Ashni (talk | contribs)
Jump to: navigation, search

{{Drugcombi | base = lamotrigine | add = carbamazepine | info =

  • This combination of drugs may have possible synergistic effects. However, the pharmacokinetic drug interactions will influence the plasma levels. Dose adaptation is recommended for this combination. [1]

| start =

  • Start carbamazepine with a daily dose of 200 mg and increase dose based serum concentration if necessary. Check lamotrigines effect after 2 weeks of therapy and adapt dose if necessary. [2]

| cave =

  • Freeman et al. Mood stabilizer Combinations: A Review of Safety and Efficacy. Am J Psychiatry 1998;155:12-21
  • Schalekamp T. et al, Interacties met Psychofarmaca, Stichting Health Base, Houten, 2002.