Revision as of 09:15, 25 June 2010 by Mariska
Adding quetiapine to risperidone.
- Risperidone is principally metabolized by CYP2D6 to an active metabolite 9-OH-risperidone (paliperidone).
- Quetiapine is principally metabolized by CYP3A4 to active and inactive metabolites.
- The combination of these 2 antipsychotics seems to be irrational from a pharmacotherapeutical point of view.
- Quetiapine may have additive adverse cardiovascular effects in combination with other drugs that are known to prolong the QT interval of the electrocardiogram. 
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