Difference between revisions of "Combining-Topiramate-Lamotrigine"

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| add = lamotrigine
 
| add = lamotrigine
 
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* Topiramate induces CYP3A4 and is an inhibiter of CYP2C19.
+
* Topiramate induces CYP3A4 and is an inhibitor of CYP2C19.
 
* Lamotrigine is principally metabolised by UDP-glucuronosyltransferases.
 
* Lamotrigine is principally metabolised by UDP-glucuronosyltransferases.
* This combination of drugs may have possible synergistic effects. However, this combination will also have additive side effects. Dose adaptation will be recommended for this combination.
+
* {{PossibleSynergisticEffects}}
 
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* Topiramate does not cause a significant change in lamotrigine levels. <ref> {{Pubmed|12180999|Berry at al, Lack of an effect of topiramate on lamotrigine serum concentrations. Epilepsia 2002;43(8):818-23}}</ref> Start topiramate according to the general dosing advice.  
 
* Topiramate does not cause a significant change in lamotrigine levels. <ref> {{Pubmed|12180999|Berry at al, Lack of an effect of topiramate on lamotrigine serum concentrations. Epilepsia 2002;43(8):818-23}}</ref> Start topiramate according to the general dosing advice.  
 
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Revision as of 09:55, 5 March 2010

Topiramate
Type moodstabilizer
Group anticonvulsant
links
ATC-code N03AX11
PubChem 5284627
PubMed Topiramate
Drugs.com topiramate
Kompas (Dutch) Topiramate
Wikipedia Topiramate
Lamotrigine
Type moodstabilizer
Group anticonvulsant
links
ATC-code N03AX09
PubChem 3878
PubMed Lamotrigine
Drugs.com lamotrigine
Kompas (Dutch) Lamotrigine
Wikipedia Lamotrigine

Adding lamotrigine to topiramate.

Infobord.png General information
  • Topiramate induces CYP3A4 and is an inhibitor of CYP2C19.
  • Lamotrigine is principally metabolised by UDP-glucuronosyltransferases.
  • Topiramate induces CYP3A4 and is an inhibitor of CYP2C19.
  • Lamotrigine is principally metabolised by UDP-glucuronosyltransferases.
  • This combination of drugs may have possible synergistic effects. However, the pharmacokinetic drug interactions will influence the plasma levels. Dose adaptation will be recommended for this combination.
Eenrichtingbord.png Start lamotrigine
  • Topiramate does not cause a significant change in lamotrigine levels. [4] Start topiramate according to the general dosing advice.



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