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Combining-Topiramate-Lamotrigine

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* Topiramate induces CYP3A4 and is an inhibiter of CYP2C19.
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* Topiramate induces CYP3A4 and is an inhibitor of CYP2C19.
* Lamotrigine is principally metabolised by UDP-glucuronosyltransferases.
* Lamotrigine is principally metabolised by UDP-glucuronosyltransferases.
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* This combination of drugs may have possible synergistic effects. However, this combination will also have additive side effects. Dose adaptation will be recommended for this combination.
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* {{PossibleSynergisticEffects}}
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* Topiramate does not cause a significant change in lamotrigine levels. <ref> {{Pubmed|12180999|Berry at al, Lack of an effect of topiramate on lamotrigine serum concentrations. Epilepsia 2002;43(8):818-23}}</ref> Start topiramate according to the general dosing advice.  
* Topiramate does not cause a significant change in lamotrigine levels. <ref> {{Pubmed|12180999|Berry at al, Lack of an effect of topiramate on lamotrigine serum concentrations. Epilepsia 2002;43(8):818-23}}</ref> Start topiramate according to the general dosing advice.  
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Revision as of 08:55, 5 March 2010

Topiramate
Type moodstabilizer
Group anticonvulsant
links
ATC-code N03AX11
PubChem 5284627
PubMed Topiramate
Drugs.com topiramate
Kompas (Dutch) Topiramate
Wikipedia Topiramate
Lamotrigine
Type moodstabilizer
Group anticonvulsant
links
ATC-code N03AX09
PubChem 3878
PubMed Lamotrigine
Drugs.com lamotrigine
Kompas (Dutch) Lamotrigine
Wikipedia Lamotrigine

Adding lamotrigine to topiramate.

Infobord.png General information
Eenrichtingbord.png Start lamotrigine



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