Combining-Topiramate-Quetiapine

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Topiramate
Type moodstabilizer
Group anticonvulsant
links
ATC-code N03AX11
PubChem 5284627
PubMed Topiramate
Drugs.com topiramate
Kompas (Dutch) Topiramate
Wikipedia Topiramate
Quetiapine
Type antipsychotic
Group atypical AP
Other use moodstabilizer
links
ATC-code N05AH04
Medscape Quetiapine
PubChem 5002
PubMed Quetiapine
Drugs.com quetiapine-fumarate
Kompas (Dutch) Quetiapine
Wikipedia Quetiapine

Adding quetiapine to topiramate.

Infobord.png General information
  • Topiramate induces CYP3A4 and is an inhibitor of CYP2C19.
  • Quetiapine is principally metabolized by CYP3A4 to active and inactive metabolites.
  • This combination of drugs may have possible synergistic effects. However, this combination will also have additive side effects. Dose adaptation will be recommended for this combination.
Eenrichtingbord.png Start quetiapine
  • Start quetiapine according general dosing advice.
Letopbord.png Cave
  • Caution is advised when topiramate is prescribed with other drugs that predispose patients to heat-related disorders, including carbonic anhydrase inhibitors and drugs with anticholinergic activity. [6]


  1. 1.0 1.1 Farmacotherapeutisch Kompas - topiramaat (dutch)
  2. 2.0 2.1 2.2 KNMP; Informatorium Medicamentorum 2023; Monografie "quetiapine" (Dutch)
  3. NVZA; Toxicology.org; Monografie 73 (dutch)
  4. Woods SW Chlorpromazine equivalent doses for the newer atypical antipsychotics J Clin Psychiatry 2003;64:663-667
  5. Drugs.com quetiapine-fumarate
  6. Interactions between quetiapine and topiramate on drugs.com
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