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Combining-Valproic acid-Quetiapine

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| add = quetiapine
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* Valproic acid is principally metabolized by CYP2C9, CYP2C19, CYP2A6 and UDP-glucuronosyltransferases. Valproic acid is an inhibitor of the enzymes CYP2C9, epoxide-hydroxylase and UDP-glucuronosyltransferases. 
 
* This combination of drugs may have possible synergistic effects. However, this combination will also have additive side effects. Dose adaptation will be recommended for this combination. <ref> {{Pubmed|18579216|Vieta E at al, Efficacy and safety of quetiapine in combination with lithium or divalproex for maintenance of patients with bipolar I disorder (international trial 126). J Affect Disord. 2008 Aug;109(3):251-63. Epub 2008 Jun 24}}</ref>
* This combination of drugs may have possible synergistic effects. However, this combination will also have additive side effects. Dose adaptation will be recommended for this combination. <ref> {{Pubmed|18579216|Vieta E at al, Efficacy and safety of quetiapine in combination with lithium or divalproex for maintenance of patients with bipolar I disorder (international trial 126). J Affect Disord. 2008 Aug;109(3):251-63. Epub 2008 Jun 24}}</ref>
| start =  
| start =  
* Start quetiapine according to the general dosing advice.
* Start quetiapine according to the general dosing advice.
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* During concomitant use of these drugs, patients should be monitored for potentially excessive or prolonged CNS and respiratory depression. <ref name="drugscom">
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* During concomitant use of these drugs, patients should be monitored for potentially excessive or prolonged CNS and respiratory depression. <ref name="drugscomint">
{{Drugscominteract|quetiapine-with-valproic-acid-1979-1274-2286-0|quetiapine|valproic acid}}</ref>   
{{Drugscominteract|quetiapine-with-valproic-acid-1979-1274-2286-0|quetiapine|valproic acid}}</ref>   
}}
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Current revision as of 09:45, 25 June 2010

Valproic acid
Type moodstabilizer
Group anticonvulsant
links
ATC-code N03AG01
PubChem 3121
PubMed acid%22 Valproic acid
Drugs.com valproic-acid
Kompas (Dutch) Valproic acid
Wikipedia Valproic acid
Quetiapine
Type antipsychotic
Group atypical AP
Other use moodstabilizer
links
ATC-code N05AH04
Medscape Quetiapine
PubChem 5002
PubMed Quetiapine
Drugs.com quetiapine-fumarate
Kompas (Dutch) Quetiapine
Wikipedia Quetiapine

Adding quetiapine to valproic acid.

Infobord.png General information
Eenrichtingbord.png Start quetiapine
Letopbord.png Cave


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