Adding ziprasidone to aripiprazole.
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- Aripiprazole is metabolized by CYP2D6 and CYP3A4 to an active metabolite.
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- Ziprasidone is metabolized by CYP1A2 (minor) and CYP3A4.
- This combination of drugs may have possible synergistic effects. However, this combination will also have additive side effects.
- Start ziprasidone according to the general dosing advice.
- Agents with anticholinergic properties may have additive effects when used in combination.
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