Difference between revisions of "Dosulepine-moclobemide"

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* '''Before day 1:''' gradually reduce dosage of dosulepine to a maximum of 75 mg/ day, when this dosage is > 75 mg/day.
* '''Day 1-3:''' reduce dosage of dosulepine to 50 mg/day.
* '''Day 4-7:''' reduce dosage of dosulepine to 25 mg/day.
* '''Day 8:''' stop administration of dosulepine.
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* '''Day 8-14:''' a wash-out period of one week is necessary.
* '''Day 15:''' start administration of moclobemide in a dosage of 150 mg/day.
* '''Day 18:''' increase dosage of moclobemide to 300 mg/day.

Latest revision as of 14:31, 16 June 2016

Type antidepressant
Group TCA
ATC-code N06AA16
PubChem 13473
PubMed dosulepin
Kompas (Dutch) dosulepin
Wikipedia dosulepin
Type Antidepressant
Group MAO-I
Medscape Moclobemide
PubChem 4235
PubMed Moclobemide
Kompas (Dutch) Moclobemide
Wikipedia Moclobemide

Switch medication from dosulepine to moclobemide.

Nietinrijdenbord.png Stop dosulepine
  • Decrease with about 25% of original dose every 3 days
  • Stop and wait 7 days for washout
Eenrichtingbord.png Start moclobemide
  • Start at the first day after the washout week with about 25% of target dose.

  1. 1.0 1.1 1.2 1.3 1.4 KNMP; Informatorium Medicamentorum 2015; Monografie "dosulepine" (Dutch)
  2. NVZA; Toxicology.org; Monografie 63 (dutch)
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