Difference between revisions of "Doxepine-imipramine"

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{{Drugswitch  
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{{Drugswitch
| from = doxepin
+
| from = doxepine
| to = imipramine
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| to = imipramine  
 
| stop =  
 
| stop =  
* Gradually reduce dosage of doxepin to a maximum of 50 mg/day.
+
{{TCAdecrease25p3d}}
* When a dosage of 50 mg/day is reached, stop administration.
 
 
| start =  
 
| start =  
 
* No wash-out period is needed.  
 
* No wash-out period is needed.  
* Start administration of imipramine the next day in a normal dosage of 50-100 mg/day.
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{{TCAincrease25p3d}}
 
| info =
 
| info =
 
* {{TCAantichol}}
 
* {{TCAantichol}}
{{review}}
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{{TCAplasmalevelmonitoring}}
 
}}
 
}}

Latest revision as of 11:25, 30 June 2023

Doxepin
Type antidepressant
Group TCA
links
ATC-code N06AA12
Medscape Doxepin
PubChem 3158
PubMed Doxepin
Drugs.com doxepin
Kompas (Dutch) Doxepin
Wikipedia Doxepin
Imipramine
Type Antidepressant
Group TCA
links
Medscape Imipramine
PubChem 3696
PubMed Imipramine
Kompas (Dutch) Imipramine
Wikipedia Imipramine

Switch medication from doxepine to imipramine.[2] [3]

Nietinrijdenbord.png Stop doxepine
  • Day 1: Decrease with about 25% of the original dose per 3 days.
Eenrichtingbord.png Start imipramine
  • No wash-out period is needed.
  • Day 1: Increase with about 25% of target dose per 3 days.
Infobord.png More information
  • Both drugs are a TCA with anticholinergic properties, so a switch to a relatively high starting dose can be made.
  • Plasma monitoring for TCA's is advisable, because of plasma-reponse relations, genetic polymorphism and under or overdosing.[4]
  1. 1.0 1.1 1.2 1.3 1.4 KNMP; Informatorium Medicamentorum 2023; Monografie "doxepine" (Dutch)
  2. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  3. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
  4. (dutch) monografie.org tricyclische-antidepressiva
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