Duloxetine-amitriptyline

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Duloxetine
Type Antidepressant
Group SNRI
links
Medscape Duloxetine
PubChem 60835
PubMed Duloxetine
Kompas (Dutch) Duloxetine
Wikipedia Duloxetine
Amitriptyline
Type Antidepressant
Group TCA
links
ATC-code N06AA09
Medscape Amitriptyline
PubChem 2160
PubMed Amitriptyline
Kompas (Dutch) Amitriptyline
Wikipedia Amitriptyline

Switch medication from duloxetine to amitriptyline.

Nietinrijdenbord.png Stop duloxetine
  • Day 0: gradually reduce dosage of duloxetine to a maximum of 60 mg/ day, when this dosage is > 60 mg/day.
  • Day 1: reduce dosage of duloxetine to a maximum of 30 mg/day.
  • Day 8: stop administration of duloxetine.
Eenrichtingbord.png Start amitriptyline

A wash-out period of one week is necessary.

  • Day 8-14: wash-out period.
  • Day 15: start administration of amitriptyline in a low dosage of 25 mg/day.
Infobord.png More information
  • Start low, go slow for amitriptyline!
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  • Duloxetine is a moderate inhibitor of CYP2D6, which metabolizes amitriptyline