Difference between revisions of "Duloxetine-hypericum"

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* '''Day 8:''' stop administration of duloxetine.
 
* '''Day 8:''' stop administration of duloxetine.
 
| start =  
 
| start =  
* '''Day 8-15:''' a wash-out period is necessary.
+
* '''Day 8-12:''' a wash-out period is necessary.
* '''Day 16:''' start administration of hypericum in a dosage of 300 mg three times a day (900 mg/day).
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* '''Day 13:''' start administration of hypericum in a dosage of 300 mg three times a day (900 mg/day).<ref>{{Pubmed|18294328|Imai H, Kotegawa T, Tsutsumi K, Morimoto T, Eshima N, Nakano S, Ohashi K. The recovery time-course of CYP3A after induction by St John's wort administration.  Br J Clin Pharmacol. 2008 May;65(5):701-7.}}</ref>
 +
<ref>{{Pubmed|16640452|Wurglics M, Schubert-Zsilavecz M. Hypericum perforatum: a 'modern' herbal antidepressant: pharmacokinetics of active ingredients. Clin Pharmacokinet. 2006;45(5):449-68.}}</ref><ref>{{Pubmed|19593191|Derijks HJ, Janknegt R, Heerdink ER, De Koning FH, Krekels MM, Looij BJ, Egberts AC. Influence of antidepressant use on glycemic control in patients with diabetes mellitus: an open-label comparative study. J Clin Psychopharmacol. 2009 Aug;29(4):405-8.}}</ref>
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<ref name="informatorium">{{KNMP|duloxetine}}</ref>
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| caveat =
 
| caveat =
 
{{caveSS}}
 
{{caveSS}}

Revision as of 12:21, 11 August 2011

Duloxetine
Type Antidepressant
Group SNRI
links
Medscape Duloxetine
PubChem 60835
PubMed Duloxetine
Kompas (Dutch) Duloxetine
Wikipedia Duloxetine
Hypericum
Type Antidepressant
Group other
links
EMEA 10130408en
PubMed Hypericum
Kompas (Dutch) hypericum extract
Wikipedia St John's wort

Switch medication from duloxetine to hypericum.[1] [2]

Nietinrijdenbord.png Stop duloxetine
  • Before day 1: gradually reduce dosage of duloxetine to a maximum of 60 mg/day, when this dosage is > 60 mg/day.
  • Day 1: reduce dosage of duloxetine to 30 mg/day.
  • Day 8: stop administration of duloxetine.
Eenrichtingbord.png Start hypericum
  • Day 8-12: a wash-out period is necessary.
  • Day 13: start administration of hypericum in a dosage of 300 mg three times a day (900 mg/day).[3]

[4][5] [6]

Letopbord.png Cave
Infobord.png More information
  • Hypericum induces enzymes of the CYP P-450 type and P-gp type.
  • Hypericum might have MAO-inhibiting and/or COMT-inhibiting properties.
  • Many studies reported that hypericin is the main source of pharmacological effects of hypericum. However the IC50 of hypericin to inhibit MAO A and MAO B is 100- to 1000-fold higher than accessible Cmax values of hypericin after oral administration of hypericum.[7]
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