Difference between revisions of "Duloxetine-trazodone"
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| − | * '''Day | + | * '''Day 12:''' start administration of trazodone in a dosage of 100-150 mg/day. |
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* Duloxetine slows the metabolism of trazodone via CYP2D6. | * Duloxetine slows the metabolism of trazodone via CYP2D6. | ||
* {{theorSS}} | * {{theorSS}} | ||
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Revision as of 13:27, 4 November 2015
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Switch medication from duloxetine to trazodone.[1] [2]
Stop duloxetine - Before day 1: gradually reduce dosage of duloxetine to a maximum of 60 mg/ day, when this dosage is > 60 mg/day.
- Day 1: reduce dosage of duloxetine to a maximum of 30 mg/day.
- Day 8: stop administration of duloxetine.
Start trazodone- Day 12: start administration of trazodone in a dosage of 100-150 mg/day.
More information- Duloxetine slows the metabolism of trazodone via CYP2D6.
- Occurrence of the serotonin syndrome is not likely, but theoretically possible, so caution is necessary.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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