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Type Antidepressant
Group SSRI
Medscape Fluoxetine
PubChem 3386
PubMed Fluoxetine
Kompas (Dutch) Fluoxetine
Wikipedia Fluoxetine
Type Antidepressant
Group TCA
ATC-code N06AA09
Medscape Amitriptyline
PubChem 2160
PubMed Amitriptyline
Kompas (Dutch) Amitriptyline
Wikipedia Amitriptyline

Switch medication from fluoxetine to amitriptyline.

Nietinrijdenbord.png Stop fluoxetine
  • Day 0: Gradually reduce dosage of fluoxetine to a maximum of 20 mg/ day, when this dosage is > 20 mg/day.
  • Day 1: When a dosage of 20 mg/day is reached, stop administration.
Eenrichtingbord.png Start amitriptyline

Caution is necessary for at least four weeks.

  • Day 1-8: wash-out period.
  • Day 8: start administration of amitriptyline in a low dosage of 25 mg/day*
  • Day 15: if necessary, increase dosage of amitriptyline to 50-150 mg/day.
Infobord.png More information
  • Fluoxetine slows the metabolism of amitriptyline via CYP2D6.
  • Start low, go slow for amitriptyline.
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