Difference between revisions of "Fluoxetine-amitriptyline"

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| to = amitriptyline  
 
| to = amitriptyline  
 
| stop =  
 
| stop =  
* '''Before day 1:''' Gradually reduce dosage of fluoxetine to a maximum of 20 mg/ day, when this dosage is > 20 mg/day.
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{{stopFluoxetine1}}
* '''Day 1:''' When a dosage of 20 mg/day is reached, stop administration.
 
 
| start =  
 
| start =  
 
Caution is necessary for at least four weeks.
 
Caution is necessary for at least four weeks.
* '''Day 1:''' start administration of amitriptyline in a low dosage of 25 mg/day.  
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* '''Day 2:''' start administration of amitriptyline in a low dosage of 25 mg/day.  
* '''Day 14:''' increase dosage of amitriptyline to 50 mg/day.
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* '''Day 15:''' increase dosage of amitriptyline to 50 mg/day.
* '''Day 28:''' gradually increase dosage of amitriptyline.
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* '''Day 29:''' gradually increase dosage of amitriptyline.
 
| info =  
 
| info =  
 
* Fluoxetine and norfluoxetine slow the metabolism of amitriptyline via CYP2D6.  
 
* Fluoxetine and norfluoxetine slow the metabolism of amitriptyline via CYP2D6.  
 
* Start low, go slow for amitriptyline.
 
* Start low, go slow for amitriptyline.
 
* {{theorSS}}
 
* {{theorSS}}
{{review}}
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}}
 
}}

Latest revision as of 14:40, 28 October 2015

Fluoxetine
Type Antidepressant
Group SSRI
links
Medscape Fluoxetine
PubChem 3386
PubMed Fluoxetine
Kompas (Dutch) Fluoxetine
Wikipedia Fluoxetine
Amitriptyline
Type Antidepressant
Group TCA
links
ATC-code N06AA09
Medscape Amitriptyline
PubChem 2160
PubMed Amitriptyline
Kompas (Dutch) Amitriptyline
Wikipedia Amitriptyline

Switch medication from fluoxetine to amitriptyline.

Nietinrijdenbord.png Stop fluoxetine
  • Before day 1: reduce dosage of fluoxetine with about 20 mg per week.
  • Day 1: when a dosage of 20 mg/day is reached, stop fluoxetine.
Eenrichtingbord.png Start amitriptyline

Caution is necessary for at least four weeks.

  • Day 2: start administration of amitriptyline in a low dosage of 25 mg/day.
  • Day 15: increase dosage of amitriptyline to 50 mg/day.
  • Day 29: gradually increase dosage of amitriptyline.
Infobord.png More information
  • Fluoxetine and norfluoxetine slow the metabolism of amitriptyline via CYP2D6.
  • Start low, go slow for amitriptyline.
  • Occurrence of the serotonin syndrome is not likely, but theoretically possible, so caution is necessary.
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