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Fluoxetine-bupropion

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* Gradually reduce dosage of fluoxetine to a maximum of 20 mg/ day, when this dosage is > 20 mg/day.
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* When a dosage of 20 mg/day is reached, stop administration.
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* '''Day 1-28:''' administration of bupropion in a low dosage of 150 mg/day.
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* '''Day 2:''' start administration of bupropion in a low dosage of 150 mg/day.
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* '''Day 29 and on:''' if necessary increase bupropion to 300 mg/day.
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* '''Day 30:''' if necessary gradually increase bupropion to 300 mg/day.
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* Bupropion inhibits CYP2D6 which metabolizes fluoxetine.
* Bupropion inhibits CYP2D6 which metabolizes fluoxetine.
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* Because of the normal half-life of 1 week of desmethylfluoxetine, there should be a low dosing of bupropion during 4 weeks.
* Because of the normal half-life of 1 week of desmethylfluoxetine, there should be a low dosing of bupropion during 4 weeks.
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Current revision as of 10:25, 28 October 2015

Fluoxetine
Type Antidepressant
Group SSRI
links
Medscape Fluoxetine
PubChem 3386
PubMed Fluoxetine
Kompas (Dutch) Fluoxetine
Wikipedia Fluoxetine
Bupropion
Type Antidepressant
Group other
links
ATC-code N06AX12
Medscape Bupropion
PubChem 444
PubMed Bupropion
Kompas (Dutch) Bupropion
Wikipedia Bupropion

Switch medication from fluoxetine to bupropion.

Nietinrijdenbord.png Stop fluoxetine
Eenrichtingbord.png Start bupropion
Infobord.png More information
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