Difference between revisions of "Fluoxetine-bupropion"

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| to = bupropion  
 
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* Gradually reduce dosage of fluoxetine to a maximum of 20 mg/ day, when this dosage is > 20 mg/day.
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{{stopFluoxetine1}}
* When a dosage of 20 mg/day is reached, stop administration.
 
 
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| start =  
* '''Day 1-28:''' administration of bupropion in a low dosage of 150 mg/day.
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* '''Day 2:''' start administration of bupropion in a low dosage of 150 mg/day.
* '''Day 29 and on:''' if necessary increase bupropion to 300 mg/day.
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* '''Day 30:''' if necessary gradually increase bupropion to 300 mg/day.
  
 
| info =
 
| info =
 
* Bupropion inhibits CYP2D6 which metabolizes fluoxetine.
 
* Bupropion inhibits CYP2D6 which metabolizes fluoxetine.
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{{longt1/2fluvox}}
 
* Because of the normal half-life of 1 week of desmethylfluoxetine, there should be a low dosing of bupropion during 4 weeks.
 
* Because of the normal half-life of 1 week of desmethylfluoxetine, there should be a low dosing of bupropion during 4 weeks.
{{review}}
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Latest revision as of 12:25, 28 October 2015

Fluoxetine
Type Antidepressant
Group SSRI
links
Medscape Fluoxetine
PubChem 3386
PubMed Fluoxetine
Kompas (Dutch) Fluoxetine
Wikipedia Fluoxetine
Bupropion
Type Antidepressant
Group other
links
ATC-code N06AX12
Medscape Bupropion
PubChem 444
PubMed Bupropion
Kompas (Dutch) Bupropion
Wikipedia Bupropion

Switch medication from fluoxetine to bupropion.

Nietinrijdenbord.png Stop fluoxetine
  • Before day 1: reduce dosage of fluoxetine with about 20 mg per week.
  • Day 1: when a dosage of 20 mg/day is reached, stop fluoxetine.
Eenrichtingbord.png Start bupropion
  • Day 2: start administration of bupropion in a low dosage of 150 mg/day.
  • Day 30: if necessary gradually increase bupropion to 300 mg/day.
Infobord.png More information
  • Bupropion inhibits CYP2D6 which metabolizes fluoxetine.
  • Fluoxetine and its metababolite desmethyl-fluoxetine have a very long elimination time of about 1 week; phasing out fluoxetine is therefore not necessary.
  • Because of the normal half-life of 1 week of desmethylfluoxetine, there should be a low dosing of bupropion during 4 weeks.
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