Difference between revisions of "Fluoxetine-citalopram"

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| start =  
 
| start =  
 
* No wash-out period is needed.  
 
* No wash-out period is needed.  
* '''Day 1:''' start citalopram/escitalopram the next day in low dosage of 10 mg/day, resp. 5 mg/day.
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* '''Day 1:''' start citalopram the next day in low dosage of 10 mg/day.
* '''Day 14:''' increase dosage of citalopram/escitalopram to normal, i.e. 20 mg/day, resp. 10 mg/day.
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* '''Day 14:''' increase dosage of citalopram to normal, i.e. 20 mg/day.
 
| info =  
 
| info =  
 
* Fluoxetine has a very long elimination time; phasing out fluoxetine is therefore not necessary.  
 
* Fluoxetine has a very long elimination time; phasing out fluoxetine is therefore not necessary.  
 
* {{theorSS}}
 
* {{theorSS}}
* Fluoxetine inhibits CYP2C19, CYP2D6 and CYP3A4, which metabolize (es)citalopram.
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* Fluoxetine inhibits CYP2C19, CYP2D6 and CYP3A4, which metabolize citalopram.
 
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Revision as of 00:27, 5 March 2010

Fluoxetine
Type Antidepressant
Group SSRI
links
Medscape Fluoxetine
PubChem 3386
PubMed Fluoxetine
Kompas (Dutch) Fluoxetine
Wikipedia Fluoxetine
Citalopram
Type Antidepressant
Group SSRI
links
ATC-code N06AB04
Medscape Citalopram
PubChem 2771
PubMed Citalopram
Kompas (Dutch) citalopram
Wikipedia citalopram

Switch medication from fluoxetine to citalopram.

Nietinrijdenbord.png Stop fluoxetine
  • Gradually reduce dosage of fluoxetine to a maximum of 20 mg/ day, when this dosage is > 20 mg/day.
  • When a dosage of 20 mg/day is reached, stop administration.
Eenrichtingbord.png Start citalopram
  • No wash-out period is needed.
  • Day 1: start citalopram the next day in low dosage of 10 mg/day.
  • Day 14: increase dosage of citalopram to normal, i.e. 20 mg/day.
Infobord.png More information
  • Fluoxetine has a very long elimination time; phasing out fluoxetine is therefore not necessary.
  • Occurrence of the serotonin syndrome is not likely, but theoretically possible, so caution is necessary.
  • Fluoxetine inhibits CYP2C19, CYP2D6 and CYP3A4, which metabolize citalopram.
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