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Type Antidepressant
Group SSRI
Medscape Fluvoxamine
PubChem 5324346
PubMed Fluvoxamine
Kompas (Dutch) Fluvoxamine
Wikipedia Fluvoxamine
Type Antidepressant
Group TCA
ATC-code N06AA09
Medscape Amitriptyline
PubChem 2160
PubMed Amitriptyline
Kompas (Dutch) Amitriptyline
Wikipedia Amitriptyline

Switch medication from fluvoxamine to amitriptyline.

Nietinrijdenbord.png Stop fluvoxamine
  • Day 0: gradually reduce dosage of fluvoxamine to a maximum of 100 mg/day when the dosage is > 100 mg/day.
  • Day 1: reduce dosage of fluvoxamine to a maximum of 50 mg/day.
  • Day 8: stop administration of fluvoxamine
Eenrichtingbord.png Start amitriptyline

Caution is necessary.

  • Day 1: simultaneously start administration of amitriptyline in a low dosage of 25 mg/day.
  • Day 8: continue administration of amitriptyline in a dosage of 50 mg/day.
  • Start low, go slow!
Infobord.png More information
  • Fluvoxamine slows the metabolism of amitriptyline via CYP1A2 and CYP2D6.
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