Fluvoxamine-amitriptyline

From Psychiatrienet
Revision as of 13:07, 5 June 2009 by Mariska (talk | contribs)
Jump to: navigation, search
Fluvoxamine
Type Antidepressant
Group SSRI
links
Medscape Fluvoxamine
PubChem 5324346
PubMed Fluvoxamine
Kompas (Dutch) Fluvoxamine
Wikipedia Fluvoxamine
Amitriptyline
Type Antidepressant
Group TCA
links
ATC-code N06AA09
Medscape Amitriptyline
PubChem 2160
PubMed Amitriptyline
Kompas (Dutch) Amitriptyline
Wikipedia Amitriptyline

Switch medication from fluvoxamine to amitriptyline.[1] [2]

Nietinrijdenbord.png Stop fluvoxamine
  • Day 0: gradually reduce dosage of fluvoxamine to a maximum of 100 mg/day when the dosage is > 100 mg/day.
  • Day 1: reduce dosage of fluvoxamine to a maximum of 50 mg/day.
  • Day 8: stop administration of fluvoxamine
Eenrichtingbord.png Start amitriptyline

Caution is necessary.

  • Day 1: simultaneously start administration of amitriptyline in a low dosage of 25 mg/day.
  • Day 8: continue administration of amitriptyline in a dosage of 50 mg/day.
  • Start low, go slow!
Infobord.png More information
  • Fluvoxamine slows the metabolism of amitriptyline via CYP1A2 and CYP2D6.
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
The editors of psychiatrienet.nl take the greatest care to provide up-to-date and accurate information on this site. Nevertheless, mistakes and omissions cannot be entirely excluded. No rights devolve from the information provided. The editors and other providers of information to this site accept no responsibility for the content of this site or for the information provided therein; neither do they accept responsibility for possible damages which may derive from the use of the information on this site or from the linked sites. The editorial board accepts no responsibility for the content of the (linked) sites, for access to them, or for the products and services on these sites, nor for the occurrence of errors, viruses, and/or disruptions in service.