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Type Antidepressant
Group SSRI
Medscape Fluvoxamine
PubChem 5324346
PubMed Fluvoxamine
Kompas (Dutch) Fluvoxamine
Wikipedia Fluvoxamine
Type Antidepressant
Group TCA
ATC-code N06AA04
Medscape Clomipramine
PubChem 2801
PubMed Clomipramine
Kompas (Dutch) Clomipramine
Wikipedia Clomipramine

Switch medication from fluvoxamine to clomipramine.

Nietinrijdenbord.png Stop fluvoxamine
  • Day 0: gradually reduce dosage of fluvoxamine to a maximum of 50 mg/ day when this dosage is > 50 mg/day.
  • Day 1: reduce dosage of fluvoxamine to a maximum of 25 mg/day.
Eenrichtingbord.png Start clomipramine

Caution is necessary.

  • Day 1: simultaneously start administration of clomipramine in a low dosage of 25-50 mg/day.
  • Day 8: stop administration of fluvoxamine and continue administration of clomipramine in a dosage of 50-75 mg/day.
  • Start low, go slow!
Infobord.png More information
  • Fluvoxamine slows the metabolism of clomipramine via CYP1A2 and CYP2D6.
  • Occurrence of the serotonin syndrome is not likely, but theoretically possible, so caution is necessary.
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