Difference between revisions of "Fluvoxamine-imipramine"

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* '''Day 1:''' reduce dosage of fluvoxamine to a maximum of 25 mg/day.  
 
* '''Day 1:''' reduce dosage of fluvoxamine to a maximum of 25 mg/day.  
 
| start =  
 
| start =  
Caution is necessary.
 
 
* '''Day 1:''' simultaneously start administration of imipramine in a low dosage of 25 mg/day.
 
* '''Day 1:''' simultaneously start administration of imipramine in a low dosage of 25 mg/day.
 
* '''Day 8:''' stop administration of fluvoxamine and continue administration of imipramine in a dosage of 50 mg/day.  
 
* '''Day 8:''' stop administration of fluvoxamine and continue administration of imipramine in a dosage of 50 mg/day.  
 
* Start low, go slow!
 
* Start low, go slow!
 
| info =  
 
| info =  
* Fluvoxamine slows the metabolism of imipramine via CYP1A2 and CYP2D6.
+
* Fluvoxamine is an inhibitor of CYP1A2, CYP2C19 and CYP3A4 (moderate), which metabolize imipramine.
 
* {{theorSS}}
 
* {{theorSS}}
 
}}
 
}}

Revision as of 15:18, 26 March 2010

Fluvoxamine
Type Antidepressant
Group SSRI
links
Medscape Fluvoxamine
PubChem 5324346
PubMed Fluvoxamine
Kompas (Dutch) Fluvoxamine
Wikipedia Fluvoxamine
Imipramine
Type Antidepressant
Group TCA
links
Medscape Imipramine
PubChem 3696
PubMed Imipramine
Kompas (Dutch) Imipramine
Wikipedia Imipramine

Switch medication from fluvoxamine to imipramine.[1] [2]

Nietinrijdenbord.png Stop fluvoxamine
  • Before day 1: gradually reduce dosage of fluvoxamine to a maximum of 50 mg/ day when this dosage is > 50 mg/day.
  • Day 1: reduce dosage of fluvoxamine to a maximum of 25 mg/day.
Eenrichtingbord.png Start imipramine
  • Day 1: simultaneously start administration of imipramine in a low dosage of 25 mg/day.
  • Day 8: stop administration of fluvoxamine and continue administration of imipramine in a dosage of 50 mg/day.
  • Start low, go slow!
Infobord.png More information
  • Fluvoxamine is an inhibitor of CYP1A2, CYP2C19 and CYP3A4 (moderate), which metabolize imipramine.
  • Occurrence of the serotonin syndrome is not likely, but theoretically possible, so caution is necessary.
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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