Difference between revisions of "Hypericum-amitriptyline"
From Psychiatrienet
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* Administration of hypericum can be stopped abruptly. | * Administration of hypericum can be stopped abruptly. | ||
| start = | | start = | ||
| − | * '''Day 1- | + | * '''Day 1-14:''' a wash-out period of one week is necessary. |
| − | * '''Day | + | * '''Day 15:''' start administration of amitriptyline in a dosage of 25 mg/day. |
* If necessary, increase dosage of amitriptyline to 50 mg/day. | * If necessary, increase dosage of amitriptyline to 50 mg/day. | ||
* Start low, go slow. | * Start low, go slow. | ||
Revision as of 16:15, 13 July 2009
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Switch medication from hypericum to amitriptyline.[1] [2]
Stop hypericum - Administration of hypericum can be stopped abruptly.
Start amitriptyline- Day 1-14: a wash-out period of one week is necessary.
- Day 15: start administration of amitriptyline in a dosage of 25 mg/day.
- If necessary, increase dosage of amitriptyline to 50 mg/day.
- Start low, go slow.
More information- Occurrence of the serotonin syndrome is theoretically possible.
- Hypericum slows the metabolism of amitriptyline via CYP3A4. This effect may persist up to two weeks after stopping hypericum, so caution is necessary.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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