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Type Antidepressant
Group other
EMEA 10130408en
PubMed Hypericum
Kompas (Dutch) hypericum extract
Wikipedia St John's wort
Type Antidepressant
Group TCA
ATC-code N06AA09
Medscape Amitriptyline
PubChem 2160
PubMed Amitriptyline
Kompas (Dutch) Amitriptyline
Wikipedia Amitriptyline

Switch medication from hypericum to amitriptyline.

Nietinrijdenbord.png Stop hypericum
  • Administration of hypericum can be stopped abruptly.
Eenrichtingbord.png Start amitriptyline
  • Day 1-7: a wash-out period of one week is necessary.
  • Day 8: start administration of amitriptyline in a dosage of 25 mg/day.
  • If necessary, increase dosage of amitriptyline to 50 mg/day.
  • Start low, go slow.
Infobord.png More information
  • Occurrence of the serotonin syndrome is theoretically possible.
  • Hypericum slows the metabolism of amitriptyline via CYP3A4. This effect may persist up to two weeks after stopping hypericum, so caution is necessary.
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