Difference between revisions of "Hypericum-citalopram"

From Psychiatrienet
Jump to: navigation, search
Line 9: Line 9:
* '''Day 31:''' start citalopram 20 mg/day.
* '''Day 31:''' start citalopram 20 mg/day.
| caveat =  
| caveat =  
* Occurrence of the serotonin syndrome is possible without wash-out period.
* Occurrence of the serotonin syndrome is possible without wash-out period.{{Lit-SSRI-Hypericum}} {{Lit-SSRI-Hypericum2}}
| info = {{HypericumInfo}}
| info = {{HypericumInfo}}

Revision as of 16:31, 12 March 2010

Type Antidepressant
Group other
EMEA 10130408en
PubMed Hypericum
Kompas (Dutch) hypericum extract
Wikipedia St John's wort
Type Antidepressant
Group SSRI
ATC-code N06AB04
Medscape Citalopram
PubChem 2771
PubMed Citalopram
Kompas (Dutch) citalopram
Wikipedia citalopram

Switch medication from hypericum to citalopram.

Nietinrijdenbord.png Stop hypericum
  • Day 1-14:Gradually decrease the dosage of hypericum.
  • Day 15: stop administration of hypericum.
Eenrichtingbord.png Start citalopram
  • Day 15-30: a wash-out period of at least two weeks is necessary.
  • Day 31: start citalopram 20 mg/day.
Letopbord.png Cave
  • Occurrence of the serotonin syndrome is possible without wash-out period.[1] [2]
Infobord.png More information
  • Hypericum induces enzymes of the CYP P-450 type and P-gp type.
  • Hypericum might have MAO-inhibiting and/or COMT-inhibiting properties.
  • Many studies reported that hypericin is the main source of pharmacological effects of hypericum. However the IC50 of hypericin to inhibit MAO A and MAO B is 100- to 1000-fold higher than accessible Cmax values of hypericin after oral administration of hypericum.[3]
  • The T1/2 of hypericum is 19 - 37 hour.[4]
The editors of psychiatrienet.nl take the greatest care to provide up-to-date and accurate information on this site. Nevertheless, mistakes and omissions cannot be entirely excluded. No rights devolve from the information provided. The editors and other providers of information to this site accept no responsibility for the content of this site or for the information provided therein; neither do they accept responsibility for possible damages which may derive from the use of the information on this site or from the linked sites. The editorial board accepts no responsibility for the content of the (linked) sites, for access to them, or for the products and services on these sites, nor for the occurrence of errors, viruses, and/or disruptions in service.