Difference between revisions of "Imipramine-amitriptyline"

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| to = amitriptyline
 
| to = amitriptyline
 
| stop =  
 
| stop =  
* Gradually reduce dosage of imipramine to a maximum of 50-100 mg/day.
+
{{downImi}}
* When a dosage of 50-100 mg/day is reached, stop administration.
 
 
| start =  
 
| start =  
 
* No wash-out period is needed.  
 
* No wash-out period is needed.  
* Start administration of amitriptyline the next day in a normal dosage of 50-100 mg/day.
+
* ''' Day 2: ''' start administration of amitriptyline in a normal dosage of 50-100 mg/day.
 
| info =
 
| info =
 
* {{TCAantichol}}
 
* {{TCAantichol}}
{{review}}
 
 
}}
 
}}

Revision as of 13:38, 4 November 2015

Imipramine
Type Antidepressant
Group TCA
links
Medscape Imipramine
PubChem 3696
PubMed Imipramine
Kompas (Dutch) Imipramine
Wikipedia Imipramine
Amitriptyline
Type Antidepressant
Group TCA
links
ATC-code N06AA09
Medscape Amitriptyline
PubChem 2160
PubMed Amitriptyline
Kompas (Dutch) Amitriptyline
Wikipedia Amitriptyline

Switch medication from imipramine to amitriptyline.[1] [2]

Nietinrijdenbord.png Stop imipramine
  • Before day 1: Gradually reduce dosage of imipramine to a maximum of 50-100 mg/day.
  • Day 1: when a dosage of 50-100 mg/day is reached, stop administration of imipramine
Eenrichtingbord.png Start amitriptyline
  • No wash-out period is needed.
  • Day 2: start administration of amitriptyline in a normal dosage of 50-100 mg/day.
Infobord.png More information
  • Both drugs are a TCA with anticholinergic properties, so a switch to a relatively high starting dose can be made.
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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