Difference between revisions of "Imipramine-clomipramine"
From Psychiatrienet
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| to = clomipramine | | to = clomipramine | ||
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* No wash-out period is needed. | * No wash-out period is needed. | ||
| − | * | + | * ''' Day 2: ''' start administration of clomipramine in a normal dosage of 75 mg/day. |
| info = | | info = | ||
* {{TCAantichol}} | * {{TCAantichol}} | ||
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}} | }} | ||
Revision as of 14:44, 4 November 2015
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Switch medication from imipramine to clomipramine.[1] [2]
Stop imipramine - Before day 1: Gradually reduce dosage of imipramine to a maximum of 50-100 mg/day.
- Day 1: when a dosage of 50-100 mg/day is reached, stop administration of imipramine
Start clomipramine- No wash-out period is needed.
- Day 2: start administration of clomipramine in a normal dosage of 75 mg/day.
More information- Both drugs are a TCA with anticholinergic properties, so a switch to a relatively high starting dose can be made.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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