Difference between revisions of "Imipramine-venlafaxine"

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| to = venlafaxine
 
| to = venlafaxine
 
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* '''Before day 1:''' gradually reduce dosage of imipramine to a maximum of 75 mg/day.
+
{{stopImipramine}}
* '''Day 1:''' reduce dosage of imipramine to 50 mg/day.
 
* '''Day 3:''' reduce dosage of imipramine to 25 mg/day.
 
* '''Day 7:''' stop dosage of imipramine.
 
 
| start =  
 
| start =  
* '''Day 8:''' {{startVenla}}
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* '''Day 9:''' {{startVenla}}
 
| info =  
 
| info =  
* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.
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* {{theorSS}}
{{review}}
 
 
}}
 
}}

Revision as of 13:46, 4 November 2015

Imipramine
Type Antidepressant
Group TCA
links
Medscape Imipramine
PubChem 3696
PubMed Imipramine
Kompas (Dutch) Imipramine
Wikipedia Imipramine
Venlafaxine
Type Antidepressant
Group SNRI
links
Medscape Venlafaxine
PubChem 5656
PubMed Venlafaxine
Kompas (Dutch) Venlafaxine
Wikipedia Venlafaxine

Switch medication from imipramine to venlafaxine.[1] [2]

Nietinrijdenbord.png Stop imipramine
  • Before day 1: gradually reduce dosage of imipramine to a maximum of 75 mg/ day, when this dosage is > 75 mg/day.
  • Day 1-3: reduce dosage of imipramine to 50 mg/day.
  • Day 4-7: reduce dosage of imipramine to 25 mg/day.
  • Day 8: stop administration of imipramine.
Eenrichtingbord.png Start venlafaxine
  • Day 9: Start administration of venlafaxine in a normal dosage of 37,5 mg or 75 mg (slow release) /day.
Infobord.png More information
  • Occurrence of the serotonin syndrome is not likely, but theoretically possible, so caution is necessary.
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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