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Maprotiline-fluoxetine

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* '''Before day 1:''' gradually reduce dosage of maprotiline to a maximum of 75 mg/day.
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{{stopMaprotiline}}
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* '''Day 1:''' reduce dosage of maprotiline to 50 mg/day.
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* '''Day 7:''' reduce dosage of maprotiline to 25 mg/day.
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* '''Day 14:''' stop dosage of maprotiline.
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| start =  
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* '''Day 7:''' simultaneously start administration of fluoxetine in a normal dosage of 20 mg/day.
* '''Day 7:''' simultaneously start administration of fluoxetine in a normal dosage of 20 mg/day.
* '''Day 14:''' stop administration of maprotiline and continue administration of fluoxetine.
* '''Day 14:''' stop administration of maprotiline and continue administration of fluoxetine.
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| info =  
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* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.
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* {{theorSS}}
* Fluoxetine is a strong inhibitor of CYP2D6, which metabolizes maprotiline.   
* Fluoxetine is a strong inhibitor of CYP2D6, which metabolizes maprotiline.   
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{{review}}
 
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Current revision as of 12:52, 2 November 2015

Maprotiline
Type Antidepressant
Group NRI
links
Medscape Maprotiline
PubChem 4011
PubMed Maprotiline
Kompas (Dutch) Maprotiline
Wikipedia Maprotiline
Fluoxetine
Type Antidepressant
Group SSRI
links
Medscape Fluoxetine
PubChem 3386
PubMed Fluoxetine
Kompas (Dutch) Fluoxetine
Wikipedia Fluoxetine

Switch medication from maprotiline to fluoxetine.

Nietinrijdenbord.png Stop maprotiline
Eenrichtingbord.png Start fluoxetine
Infobord.png More information
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