Maprotiline-sertraline

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Maprotiline
Type Antidepressant
Group NRI
links
Medscape Maprotiline
PubChem 4011
PubMed Maprotiline
Kompas (Dutch) Maprotiline
Wikipedia Maprotiline
Sertraline
Type Antidepressant
Group SSRI
links
Medscape Sertraline
PubChem 68617
PubMed Sertraline
Kompas (Dutch) Sertraline
Wikipedia Sertraline

Switch medication from maprotiline to sertraline.

Nietinrijdenbord.png Stop maprotiline
  • Before day 1: gradually reduce dosage of maprotiline to a maximum of 75 mg/day.
  • Day 1: reduce dosage of maprotiline to 50 mg/day.
  • Day 7: reduce dosage of maprotiline to 25 mg/day.
  • Day 14: stop dosage of maprotiline.
Eenrichtingbord.png Start sertraline
  • Day 7: simultaneously start administration of sertraline in a normal dosage of 50 mg/day.
  • Day 14: stop administration of maprotiline and continue administration of sertraline in a dosage of 50-100 mg/day.
Infobord.png More information
  • Sertraline is a weak inhibitor of CYP2D6, which metabolizes maprotiline.
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