Difference between revisions of "Mirtazapine-clomipramine"

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| to = clomipramine  
 
| to = clomipramine  
 
| stop =  
 
| stop =  
* '''Before day 1:''' gradually reduce dosage of mirtazapine to a maximum of 30 mg/ day.
+
{{stopMirtazapine}}
* '''Day 1:''' reduce a dosage of 30 mg/day to 15 mg/day.
+
| start =  
| start =
+
{{Inc25p3d2}}
No wash-out period is needed.
+
* Start administration of clomipramine in a dosage of 75 mg/day.  
* '''Day 1:''' simultaneously start administration of clomipramine in a dosage of 75 mg/day.
 
* '''Day 8:''' stop administration of mirtazapine and continue administration of clomipramine. If necessary, increase dosage of clomipramine.
 
 
* Start low, go slow.
 
* Start low, go slow.
 
| info =
 
| info =
{{review}}
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* No wash-out period is needed.
 
}}
 
}}

Revision as of 11:53, 14 October 2015

Mirtazapine
Type Antidepressant
Group other
links
Medscape Mirtazapine
PubChem 4205
PubMed Mirtazapine
Kompas (Dutch) Mirtazapine
Wikipedia Mirtazapine
Clomipramine
Type Antidepressant
Group TCA
links
ATC-code N06AA04
Medscape Clomipramine
PubChem 2801
PubMed Clomipramine
Kompas (Dutch) Clomipramine
Wikipedia Clomipramine

Switch medication from mirtazapine to clomipramine.[1] [2]

Nietinrijdenbord.png Stop mirtazapine
  • Before day 1: Gradually reduce dosage of mirtazapine to a maximum of 30 mg/day, when this dosage is > 30 mg/day.
  • Day 1: Reduce dosage of mirtazapine to 15 mg/day.
  • Day 8: Stop administration of mirtazapine.
Eenrichtingbord.png Start clomipramine
  • Day 2: Start with normal dosage and increase with about 25% (up to 50%) every 3 days to target dose.
  • Start administration of clomipramine in a dosage of 75 mg/day.
  • Start low, go slow.
Infobord.png More information
  • No wash-out period is needed.
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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