Difference between revisions of "Mirtazapine-fluvoxamine"

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* '''Day 14:''' If necessary, increase dosage of fluvoxamine to 100 mg/day and later even more.  
 
* '''Day 14:''' If necessary, increase dosage of fluvoxamine to 100 mg/day and later even more.  
 
| info =  
 
| info =  
* Caution with this switch is necessary, because fluvoxamine slows the metabolism of mirtazapine via CYP1A2, CYP2C9, CYP2D6 and CYP3A4.}}
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* Caution with this switch is necessary, because fluvoxamine slows the metabolism of mirtazapine via CYP1A2, CYP2C9, CYP2D6 and CYP3A4.
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{{review}}
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Revision as of 14:20, 7 October 2015

Mirtazapine
Type Antidepressant
Group other
links
Medscape Mirtazapine
PubChem 4205
PubMed Mirtazapine
Kompas (Dutch) Mirtazapine
Wikipedia Mirtazapine
Fluvoxamine
Type Antidepressant
Group SSRI
links
Medscape Fluvoxamine
PubChem 5324346
PubMed Fluvoxamine
Kompas (Dutch) Fluvoxamine
Wikipedia Fluvoxamine

Switch medication from mirtazapine to fluvoxamine.[1] [2]

Nietinrijdenbord.png Stop mirtazapine
  • Before day 1: gradually reduce dosage of mirtazapine to a maximum of 30 mg/ day.
  • Day 1: reduce a dosage of 30 mg/day to 15 mg/day.
  • Day 8: stop administration of mirtazapine.
Eenrichtingbord.png Start fluvoxamine
  • Day 11: start fluvoxamine in a normal dosage of 50 mg/day.
  • Day 14: If necessary, increase dosage of fluvoxamine to 100 mg/day and later even more.
Infobord.png More information
  • Caution with this switch is necessary, because fluvoxamine slows the metabolism of mirtazapine via CYP1A2, CYP2C9, CYP2D6 and CYP3A4.
  • This switch is currently being reviewed.
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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