Difference between revisions of "Moclobemide-duloxetine"

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| to = duloxetine  
 
| to = duloxetine  
 
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* '''Before day 1:''' gradually reduce dosage of moclobemide to a maximum of 300 mg/day.
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{{generaldecrease25p3d}}
* '''Day 1:''' reduce the dosage of moclobemide to 150 mg/day.
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{{24Hwashout}}
* '''Day 8:''' stop administration of moclobemide.
 
 
| start =   
 
| start =   
* '''Day 8-9:''' a wash-out period of two days is necessary.
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{{generalstart}}
* '''Day 10:''' start duloxetine after this period in a normal dosage of 60 mg/day.
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|info=
 
|info=
{{review}}
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{{mocloshorthalflife}}
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* A wash-out period is not necessary.
 
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Latest revision as of 15:43, 17 June 2016

Moclobemide
Type Antidepressant
Group MAO-I
links
Medscape Moclobemide
PubChem 4235
PubMed Moclobemide
Kompas (Dutch) Moclobemide
Wikipedia Moclobemide
Duloxetine
Type Antidepressant
Group SNRI
links
Medscape Duloxetine
PubChem 60835
PubMed Duloxetine
Kompas (Dutch) Duloxetine
Wikipedia Duloxetine

Switch medication from moclobemide to duloxetine.

Nietinrijdenbord.png Stop moclobemide
  • Decrease with about 25% of original dose every 3 days
  • Stop and wait for about 24 hour as a washout period
Eenrichtingbord.png Start duloxetine
  • Start with the initial dose
Infobord.png More information
  • Because of the short half life of moclobemide (approx. 2h), the next antidepressant can start next day after stopping with moclobemide.[1]
  • A wash-out period is not necessary.
  1. Keks, Nicholas, J. Hope, and S. Keogh. "Switching and stopping antidepressants." Australian Prescriber 39.3 (2016).
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