Difference between revisions of "Moclobemide-imipramine"

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| to = imipramine  
 
| to = imipramine  
 
| stop =  
 
| stop =  
* '''Before day 1:''' gradually reduce dosage of moclobemide to a maximum of 300 mg/day.
+
{{stopMoclobemide}}
* '''Day 1:''' reduce the dosage of moclobemide to 150 mg/day.
 
* '''Day 8:''' stop administration of moclobemide.
 
 
| start =  
 
| start =  
* No wash-out period is needed.
 
 
* '''Day 9:''' start administration of imipramine the next day in a normal dosage of 25-75 mg/day.
 
* '''Day 9:''' start administration of imipramine the next day in a normal dosage of 25-75 mg/day.
 
|info=
 
|info=
{{review}}
+
* Because of short halve life of moclobemide after stopping, the next antidepressant can start next day.
 +
* No wash-out period is needed.
  
 
}}
 
}}

Revision as of 08:01, 21 October 2015

Moclobemide
Type Antidepressant
Group MAO-I
links
Medscape Moclobemide
PubChem 4235
PubMed Moclobemide
Kompas (Dutch) Moclobemide
Wikipedia Moclobemide
Imipramine
Type Antidepressant
Group TCA
links
Medscape Imipramine
PubChem 3696
PubMed Imipramine
Kompas (Dutch) Imipramine
Wikipedia Imipramine

Switch medication from moclobemide to imipramine.[1] [2]

Nietinrijdenbord.png Stop moclobemide
  • Before day 1: gradually reduce dosage of moclobemide to a maximum of 300 mg/day.
  • Day 1: reduce the dosage of moclobemide to 150 mg/day.
  • Day 8: stop administration of moclobemide.
Eenrichtingbord.png Start imipramine
  • Day 9: start administration of imipramine the next day in a normal dosage of 25-75 mg/day.
Infobord.png More information
  • Because of short halve life of moclobemide after stopping, the next antidepressant can start next day.
  • No wash-out period is needed.
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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