Difference between revisions of "Moclobemide-maprotiline"

From Psychiatrienet
Jump to: navigation, search
Line 3: Line 3:
 
| to = maprotiline  
 
| to = maprotiline  
 
| stop =  
 
| stop =  
* '''Before day 1:''' gradually reduce dosage of moclobemide to a maximum of 300 mg/day.
+
{{stopMoclobemide}}
* '''Day 1:''' reduce the dosage of moclobemide to 150 mg/day.
 
* '''Day 8:''' stop administration of moclobemide.
 
 
| start =  
 
| start =  
* No wash-out period is necessary.
+
* '''Day 9:''' start maprotiline in a normal dosage of 25-75 mg/day.
* '''Day 9:''' start maprotiline after this period in a normal dosage of 25-75 mg/day.
+
 
 +
|info=
 
* “Start low, go slow” is not required, but caution is necessary.
 
* “Start low, go slow” is not required, but caution is necessary.
|info=
+
{{Shortt1/2}}
{{review}}
 
 
}}
 
}}

Revision as of 13:50, 14 October 2015

Moclobemide
Type Antidepressant
Group MAO-I
links
Medscape Moclobemide
PubChem 4235
PubMed Moclobemide
Kompas (Dutch) Moclobemide
Wikipedia Moclobemide
Maprotiline
Type Antidepressant
Group NRI
links
Medscape Maprotiline
PubChem 4011
PubMed Maprotiline
Kompas (Dutch) Maprotiline
Wikipedia Maprotiline

Switch medication from moclobemide to maprotiline.[1] [2]

Nietinrijdenbord.png Stop moclobemide
  • Before day 1: gradually reduce dosage of moclobemide to a maximum of 300 mg/day.
  • Day 1: reduce the dosage of moclobemide to 150 mg/day.
  • Day 8: stop administration of moclobemide.
Eenrichtingbord.png Start maprotiline
  • Day 9: start maprotiline in a normal dosage of 25-75 mg/day.
Infobord.png More information
  • “Start low, go slow” is not required, but caution is necessary.
  • Because of short halve life of moclobemide after stopping, the next antidepressant can start next day.
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
The editors of psychiatrienet.nl take the greatest care to provide up-to-date and accurate information on this site. Nevertheless, mistakes and omissions cannot be entirely excluded. No rights devolve from the information provided. The editors and other providers of information to this site accept no responsibility for the content of this site or for the information provided therein; neither do they accept responsibility for possible damages which may derive from the use of the information on this site or from the linked sites. The editorial board accepts no responsibility for the content of the (linked) sites, for access to them, or for the products and services on these sites, nor for the occurrence of errors, viruses, and/or disruptions in service.