Moclobemide-sertraline

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Moclobemide
Type Antidepressant
Group MAO-I
links
Medscape Moclobemide
PubChem 4235
PubMed Moclobemide
Kompas (Dutch) Moclobemide
Wikipedia Moclobemide
Sertraline
Type Antidepressant
Group SSRI
links
Medscape Sertraline
PubChem 68617
PubMed Sertraline
Kompas (Dutch) Sertraline
Wikipedia Sertraline

Switch medication from moclobemide to sertraline.[1] [2]

Nietinrijdenbord.png Stop moclobemide
  • Decrease with about 25% of original dose every 3 days
  • Stop and wait for about 24 hour as a washout period
Eenrichtingbord.png Start sertraline
  • Start with the initial dose
Infobord.png More information
  • Caution is necessary, because occurrence of serotonin syndrome is theoretically possible.
  • Because of short halve life of moclobemide after stopping, the next antidepressant can start next day.
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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