Difference between revisions of "Nortriptyline-bupropion"

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* Bupropion is a strong inhibitor of CYP2D6, which metabolizes nortriptyline.
 
* Bupropion is a strong inhibitor of CYP2D6, which metabolizes nortriptyline.
* Caution with this switch is necessary. }}
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* Caution with this switch is necessary.  
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Revision as of 01:02, 22 March 2010

Nortriptyline
Type Antidepressant
Group TCA
links
Medscape Nortriptyline
PubChem 4543
PubMed Nortriptyline
Kompas (Dutch) Nortriptyline
Wikipedia Nortriptyline
Bupropion
Type Antidepressant
Group other
links
ATC-code N06AX12
Medscape Bupropion
PubChem 444
PubMed Bupropion
Kompas (Dutch) Bupropion
Wikipedia Bupropion

Switch medication from nortriptyline to bupropion.[1] [2]

Nietinrijdenbord.png Stop nortriptyline
  • Before day 1: gradually reduce dosage of nortriptyline to a maximum of 50 mg/day, when this dosage is > 50 mg/day.
  • Day 1-3: reduce dosage of nortriptyline to 25 mg/day.
Eenrichtingbord.png Start bupropion
  • Day 1: simultaneously start administration of bupropion in a dosage of 150 mg/day and continue administration of nortriptyline according to the scheme above.
  • Day 8: stop administration of nortriptyline and continue administration of bupropion.
Infobord.png More information
  • Bupropion is a strong inhibitor of CYP2D6, which metabolizes nortriptyline.
  • Caution with this switch is necessary.
  • The concomitant use of bupropion and tricyclic antidepressants (TCAs) may potentiate the risk of seizures. These agents are all epileptogenic and may have additive effects on the seizure threshold.
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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